{"id":40,"date":"2014-07-18T12:34:00","date_gmt":"2014-07-18T10:34:00","guid":{"rendered":"http:\/\/www.bioeconomy.it\/wp\/?p=40"},"modified":"2016-07-18T12:34:30","modified_gmt":"2016-07-18T10:34:30","slug":"le-malattie-neurodegenerative","status":"publish","type":"post","link":"https:\/\/www.bioeconomy.it\/en\/2014\/07\/18\/le-malattie-neurodegenerative\/","title":{"rendered":"Le malattie neurodegenerative"},"content":{"rendered":"

Le malattie neurodegenerative<\/strong>, tra cui le pi\u00f9 comuni patologie come l’Alzheimer<\/strong> e il morbo di Parkinson<\/strong> e le malattie pi\u00f9 rare come la malattia di Huntington<\/strong>, ancora presentano forti mancanze in termini di diagnostica (in particolare biomarcatori di progressione di malattia) e terapie in grado di arrestare o rallentare la malattia.<\/p>\n

In alcuni casi, gli eventi causali associati a queste malattie, sono chiaramente definiti grazie al loro carattere monogenetico. In altri casi, i meccanismi alla base della patologia, sono ancora oggetto di intensi studi per identificare bersagli terapeutici pi\u00f9 rilevanti per lo sviluppo di farmaci e biologici.<\/p>\n

Iniziative che mirano a ridurre il peso di specifiche proteine tossiche<\/strong> associate alle malattie, una caratteristica di molte di queste malattie, promettono di fornire benefici che mirano a risolvere la causa primaria della malattia piuttosto che agli eventi a valle. Tuttavia, questo richiede la capacit\u00e0 di individuare, quantificare e profilare queste proteine tossiche (e i loro conformeri) in campioni biologici rilevanti (modelli preclinici e patient material), in parallelo alla definizione di strategie per ridurre i loro livelli.<\/p>\n

Lo sviluppo parallelo di terapie volte a ridurre le proteine tossiche<\/em> associate alla malattia, e di saggi in grado di rilevare la loro efficacia in pazienti cos\u00ec come nei modelli preclinici, rappresenta una sfida attuale nel settore. La scoperta e lo sviluppo terapeutico, un compito tradizionalmente svolto in gran parte dall’industria farmaceutica<\/strong>, negli ultimi anni \u00e8 stato notevolmente aiutato da fondazioni ed altri istituti no-profit, che agiscono sia come agevolatori di idee, modelli e reagenti tra gli scienziati e gli sviluppatori di farmaci, cos\u00ec come sostenitori diretti di ricerca e di sviluppo in ambienti accademici e industriali.<\/p>\n

A sostegno della ricerca<\/strong> nel campo della scoperta di nuovi farmaci<\/strong> e di sviluppo per le malattie neurodegenerative<\/strong>, CNCCS <\/a>ha organizzato a Roma la IV Conferenza Internazionale<\/strong>: Bioeconomy Rome<\/strong>, dove scienziati di fama mondiale, rappresentanti del settore farmaceutico, istituzioni governative, e le parti interessate pubbliche e private, si incontrano per la discussione, lo scambio di idee e le proposte che modellano le strategie future.<\/p>\n","protected":false},"excerpt":{"rendered":"

Le malattie neurodegenerative, tra cui le pi\u00f9 comuni patologie come l’Alzheimer e il morbo di Parkinson e le malattie pi\u00f9 rare come la malattia di Huntington, ancora presentano forti mancanze in termini di diagnostica (in particolare biomarcatori di progressione di malattia) e terapie in grado di arrestare o rallentare la malattia. In alcuni casi, gli …<\/p>\n","protected":false},"author":1,"featured_media":41,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-40","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"\nLe malattie neurodegenerative - Bioeconomy Rome International Conference<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bioeconomy.it\/2014\/07\/18\/le-malattie-neurodegenerative\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Le malattie neurodegenerative - Bioeconomy Rome International Conference\" \/>\n<meta property=\"og:description\" content=\"Le malattie neurodegenerative, tra cui le pi\u00f9 comuni patologie come l’Alzheimer e il morbo di Parkinson e le malattie pi\u00f9 rare come la malattia di Huntington, ancora presentano forti mancanze in termini di diagnostica (in particolare biomarcatori di progressione di malattia) e terapie in grado di arrestare o rallentare la malattia. 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