![\"francesco-angelucci\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/angelucci.jpg\")
<\/p>\n
Obtained his degree in Chemistry in 2001 and his Ph.D. in Biochemistry in 2005 at the Department of Biochemical Sciences “A. Rossi Fanelli” of the \u201cSapienza\u201d University of Rome. Here he stayed as Post-doc until 2011. Currently, he is employed as assistant Professor at the Department of Life, Health and Environmental Sciences at the University of L\u2019 Aquila. Francesco Angelucci is mainly involved in the study of structure-function relationships of potential drug-targets from Schistosoma, the pathological agent of schistosomiasis. The final purpose of this approach is to find new therapies against this neglected disease that affects 280 million people in tropical and sub-tropical countries.<\/p>\n
- \n
- Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin Structure<\/em>. 20, 429-39 (2012)<\/a> (Abstract only)<\/li>\n
- Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem.<\/em> 284, 28977-85 (2009)<\/a><\/li>\n<\/ul>\n
<\/p>\n
PAOLA BAIOCCO<\/strong><\/p>\n
![\"paola-baiocco\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/baiocco.jpg\")
<\/p>\nDegree in chemistry in 2002 at the University of Rome \u201cLa Sapienza\u201d studying the mechanism of oxidation of benzylic alcohols and ethers from a laccase of Trametes versicolor. PhD. in Biochemistry at the Institute A. Rossi Fanelli of the University \u201cLa Sapienza\u201d working in the crystallography group of Prof. M. Brunori. Her Ph.D project was focused on the structural and functional study of pathogenically important proteins from Schistosoma mansoni. In 2006, she worked at IRBM in the crystallography group under the guide of Dr. S. Di Marco. Her study on the allosteric inhibitors of NS5B polymerase of HCV won a prize at the Merck Research Laboratories Target-to-phase IIb Symposium in Atlanta. Since 2007, she has been working in Prof. A. Boffi\u2019s group at \u201cLa Sapienza\u201d University on a project focused on the redox metabolism of Leishmania infantum. In particular, a study on the trypanothione reductase disclosed the mechanism of inhibition of antimonials, widely used as a drug against leishmaniasis.<\/p>\n
- \n
- Inhibitory effect of silver nanoparticles on Trypanothione Reductase activity and Leishmania infantum proliferation ACS Med. Chem. Letters<\/em> 2011, 2, 230-233<\/a><\/li>\n
- Molecular basis of antimony treatment in Leishmaniasis J. Med. Chem.<\/em>, 2009, 52, 2603-12<\/a><\/li>\n<\/ul>\n
CLAUDIA BINDA<\/strong><\/p>\n
![\"claudia-binda\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/binda.jpg\")
<\/p>\nWas born in Varese in 1973 and graduated in Biological Sciences in 1997 at the University of Pavia. The scientific background of Claudia Binda is in the field of structural biology of medically-relevant proteins. Her research activity mostly developed at the University of Pavia in the Structural Biology group headed by Prof. Andrea Mattevi. For more than 10 years she has been collaborating with the group of Prof. Dale Edmondson at Emory University (USA), where she spent some time of her career for biochemical studies on monoamine oxidases supported by a fellowship from a NIH grant. More recently, she has been working on Lysine-specific Demethylase 1, the first histone lysine demethylase ever discovered, and on a new tuberculosis drug target. Since 2008 she has been Assistant Professor in Molecular Biology at the University of Pavia.<\/p>\n
- \n
- Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis <\/em>Nat Struct<\/em> Biol<\/em>. 2002 Jan;9(1):22-6.<\/a><\/li>\n
- Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders Sci Transl Med<\/em>. 2012 Sep 5;4(150):<\/a> (abstract only)<\/li>\n<\/ul>\n
<\/p>\n
MARITA BOSTICARDO<\/strong><\/p>\n
![\"marita-bosticardo\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/bosticardo.jpg\")
<\/p>\nAfter completing her undergraduate studies in Biology at the University of Turin, moved to the National Human Genome Research Institute (NIH, USA). Her work ever since has been focused on gaining a better understanding of the pathogenesis of Primary Immunodeficiencies and on the development of gene therapy-based innovative therapeutic approaches for these diseases. At the NIH, she gained extensive experience in gene therapy with retroviral vectors, both in human cells and in the mouse model of IL12R\uf0621 deficiency. Since 2006 she has been working at the Telethon Institute for Gene Therapy in Milan, focusing on the evaluation of safety and efficacy of a hematopoietic stem cell-based gene therapy approach for Wiskott-Aldrich syndrome (WAS). Her work has contributed to the approval of a clinical trial of lentiviral vector-mediated gene therapy for WAS that started in 2010 at the San Raffaele Hospital in Milan and in which until now 4 WAS patients have been enrolled and successfully treated.<\/p>\n
- \n
- Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich Syndrome J Allergy Clin Immunol<\/em><\/a><\/li>\n
- Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome. Blood<\/em> Jun 18; 113(25):6288-95, 2009.<\/a><\/li>\n<\/ul>\n
BARBARA CASSANI<\/strong><\/p>\n
![\"barbara-cassani\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/cassani.jpg\")
<\/p>\nPhD, graduated in Pharmacy in 2001 at the Universita\u2019 degli Studi in Milan. She received the PhD in Cellular and Molecular Biology in 2007 working at the San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET). After a period at the ITB-CNR laboratory of Milan, from 2010 to 2012, she was senior postdoctoral fellow at the Massachusetts General Hospital, Harvard Medical School. Since 2012 she has been a research scientist in the IRGB-CNR laboratory at the Humanitas Clinical Institute. Her activity focuses mainly in the field of genetic diseases, to which she hascontributed with the identification of the pathogenic mechanisms in different forms of primary immunodeficiencies and osteopetrosis. She was honored with scholarships from national and international organizations (Marie Curie, EMBO) and awards from several international scientific societies.<\/p>\n
- \n
- Multilineage hematopoietic reconstitution without clonal selection in ADASCID patients treated with stem cell gene therapy.\u201d J Clin Invest. 2007 Aug;117(8):2233-40<\/a>.<\/li>\n
- Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome.\u201d J Exp Med. 2010 Jul 5;207(7):1525-40.<\/a><\/li>\n<\/ul>\n
<\/p>\n
MARTA GIACOMELLO<\/strong><\/p>\n
![\"marta-giacomello\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/giacomello.jpg\")
<\/p>\nGraduated in Pharmaceutical Biotechnology in 2003 at the University of Padua and in Molecular and Cellular Biology in 2011 at the University of Bologna. Marta obtained her PhD in Biotechnology in 2007, at the University of Padua. During previous research experiences in the field of Biomedical Sciences, she worked on projects whose aim was to unravel the molecular mechanisms at the basis of some diseases (such as Huntington\u2019s Corea, Alzheimer\u2019s disease, deafness), with particular emphasis on the alterations of intracellular Ca2+ homeostasis and mitochondrial activity. Marta has gained skills and expertise in Molecular and Cellular Biology, as well as in Fluorescence Microscopy, since she had the opportunity (during her Ph.D and post-doctoral fellowships) to work in laboratories with a solid background in these techniques, such as the laboratory of Professors. T.Pozzan, E.Carafoli, B Cozzi (University of Padova, Italy), R.Y. Tsien (University of San Diego, CA) and Prof. L.Scorrano.<\/p>\n
- \n
- Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not activation of store operated Ca2+ channels. Molecular Cell<\/em> 2010; 38: 280-290<\/a>.<\/em><\/li>\n
- Mitochondrial fission and cristae disruption increase the response of cell models of Huntington\u2019s disease to apoptotic stimuli. EMBO Mol Med<\/em> 2010; 2: 490-503<\/a><\/li>\n<\/ul>\n
ALESSANDRO ROSA<\/strong><\/p>\n
![\"alessandro-rosa\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/rosa.jpg\")
<\/p>\nWas born in Rieti in 1980. He has a Masters Degree in Biological Sciences and a PhD in Genetics and Molecular Biology obtained at the University of Rome (2007). During his PhD he worked on gene therapy of Duchenne Muscular Dystrophy and studied microRNAs in hematopoiesis and myeloid leukemias. As a post-doc at the Rockefeller University in New York (2007-2010), he studied microRNAs in embryonic stem cells. From 2009 to 2010 he was director of the Rockefeller Stem Cells Derivation Core. Since 2011 he returned permanently in Italy, obtaining a Researcher position at the Sapienza University, to work on Amyotrophic Lateral Sclerosis with reprogrammed stem cells (iPS). His works have been published in Cell, Dev. Cell, EMBO J, PNAS and other important international journals. He was awarded with a HFSP Fellowship, a NY Stem Cell Found. Fellowship, the Young Researcher SIBBM 2006 Award and the RNA Society 2008 Poster Award.<\/p>\n
- \n
- A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C\/EBPalpha regulates human granulopoiesis Cell<\/em> 123, 819\u2013831 (2005).<\/a><\/li>\n
- The miR-430\/427\/302 Family Controls Mesendodermal Fate Specification via Species-Specific Target Selection Dev Cell<\/em> 16, 517\u2013527 (2009).<\/a><\/li>\n<\/ul>\n
<\/h2>\n
AISHA SAUER<\/strong><\/p>\n
![\"aisha-sauer\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/sauer.jpg\")
<\/p>\nAfter completing her degree in Biology at the University of Tuebingen in Germany and the University of Queensland in Australia, Aisha moved to Italy to pursue her PhD at the San Raffaele Telethon Institute for Gene Therapy. She has since become interested in studying the pathogenesis of primary immunodeficiencies and their treatment with innovative approaches, such as gene therapy. Her work is focused on adenosine deaminase (ADA)-deficient severe combined immunodeficiency, a fatal condition unless treated. She has identified specific alterations in immune and non-immune cells in ADA-deficiency, which can be corrected by gene therapy. During a period spent at Yale University in the US she has studied the efficacy of gene therapy on immune tolerance. With 18 ADA-SCID patients successfully treated in Milan, this disease nowadays represents a paradigmatic model of gene therapy for inherited disorders. Her current work at TIGET is focused on the market registration of this innovative therapy, in order to make it available to ADA-SCID patients worldwide.<\/p>\n
- \n
- Defective B cell tolerance due to adenosine deaminase deficiency is corrected by gene therapy. J Clin Invest. 2012 Jun 1;122(6):2141\u20132152.<\/em><\/a><\/li>\n
- Alterations in the adenosine metabolism and CD39\/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID. Blood.<\/em> 2012 Feb 9;119(6):1428-1439.<\/a><\/li>\n<\/ul>\n
ANGELA SPARAGO<\/strong><\/p>\n
![\"angela-sparago\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/sparago.jpg\")
<\/p>\nAchieved her Masters in Biological Sciences in 2002 at the University of Naples Federico II and has continued her scientific activity leading to Ph.D. in Biotechnology in 2006 at the Second University of Naples. Currently she is a Telethon researcher. Her interest is in the field of human genetics and the study of causative mechanisms of\u00a0rare\u00a0congenital diseases. She has been studying the pathogenic mechanisms that underly the diseases caused by alteration in physiological dosage of genes regulated by genomic imprinting (Beckwith-Wiedemann syndrome, Silver-Russell syndrome and Wilms’ tumor). The results obtained have contributed to understanding how the genetic and epigenetic defects arise, are inherited and maintained in patients with growth alterations.<\/p>\n
- \n
- Microdeletions in the human H19<\/em> DMR result in loss of IGF2<\/em> imprinting and Beckwith-Wiedemann syndrome Nat Genet <\/em>36(9):958-60, 2004<\/a><\/li>\n
- Disruption of genomic neighbourhood at the imprinted IGF2-H19<\/em> locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome Hum Mol Genet<\/em> 20(7):1363-74, 2011<\/a><\/li>\n<\/ul>\n
MARTA VALENZA<\/strong><\/p>\n
![\"marta-valenza\"](\"http:\/\/www.bioeconomy.it\/wp-content\/uploads\/2016\/07\/valenza.jpg\")
<\/p>\n(14\/2\/77) Is a research fellow in the laboratory headed by Prof. Elena Cattaneo at University of Milan (Universit\u00e0 degli Studi). She graduated in Biological Sciences (2001) and got her doctorate degree in Biotechnology applied to Pharmacology (2006) at the University of Milan. From the beginning of her career, her research has been focused on mechanisms of action of mutant huntingtin, the protein that causes Huntington’s disease, a rare neurodegenerative disease characterized by movement disorders, cognitive and behavior.
\nMarta Valenza has contributed to identifying a decrease in the production of brain cholesterol in Huntington’s disease, identifying the underlying molecular mechanism. This dysfunction – of cerebral origin but measurable in the blood of patients – has attracted the interest of clinics for therapeutics and biomarkers researches. In 2009, she was a visiting scientist at the Centre for Molecular Medicine and Therapeutics, Vancouver (Canada), in the laboratory of Prof. Michael Hayden, a scientific leader in the research on Huntington\u2019s disease and lipids, and now president of Global Research and Development, TEVA Pharmaceutical Industries.<\/p>\n- \n
- Dysfunction of the cholesterol biosynthetic pathway in Huntington\u2019s disease J Neurosci<\/em>. 2005, 25(43):9932\u20139939<\/a><\/li>\n
- Cholesterol defect is marked across multiple rodent models of Huntington’s disease and is manifest in astrocytes J Neurosci.<\/em>2010 Aug 11;30(32):10844-50<\/a><\/li>\n<\/ul>\n
<\/p>\n
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FRANCESCO ANGELUCCI Obtained his degree in Chemistry in 2001 and his Ph.D. in Biochemistry in 2005 at the Department of Biochemical Sciences “A. Rossi Fanelli” of the \u201cSapienza\u201d University of Rome. Here he stayed as Post-doc until 2011. Currently, he is employed as assistant Professor at the Department of Life, Health and Environmental …<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-170","page","type-page","status-publish","hentry"],"yoast_head":"\n
Rewarded - Bioeconomy Rome International Conference<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bioeconomy.it\/premiati-2012\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rewarded - Bioeconomy Rome International Conference\" \/>\n<meta property=\"og:description\" content=\" FRANCESCO ANGELUCCI Obtained his degree in Chemistry in 2001 and his Ph.D. in Biochemistry in 2005 at the Department of Biochemical Sciences “A. Rossi Fanelli” of the \u201cSapienza\u201d University of Rome. Here he stayed as Post-doc until 2011. 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Rossi Fanelli” of the \u201cSapienza\u201d University of Rome. Here he stayed as Post-doc until 2011. 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- Disruption of genomic neighbourhood at the imprinted IGF2-H19<\/em> locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome Hum Mol Genet<\/em> 20(7):1363-74, 2011<\/a><\/li>\n<\/ul>\n
- Alterations in the adenosine metabolism and CD39\/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID. Blood.<\/em> 2012 Feb 9;119(6):1428-1439.<\/a><\/li>\n<\/ul>\n
- The miR-430\/427\/302 Family Controls Mesendodermal Fate Specification via Species-Specific Target Selection Dev Cell<\/em> 16, 517\u2013527 (2009).<\/a><\/li>\n<\/ul>\n
- Mitochondrial fission and cristae disruption increase the response of cell models of Huntington\u2019s disease to apoptotic stimuli. EMBO Mol Med<\/em> 2010; 2: 490-503<\/a><\/li>\n<\/ul>\n
- Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome.\u201d J Exp Med. 2010 Jul 5;207(7):1525-40.<\/a><\/li>\n<\/ul>\n
- Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome. Blood<\/em> Jun 18; 113(25):6288-95, 2009.<\/a><\/li>\n<\/ul>\n
- Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders Sci Transl Med<\/em>. 2012 Sep 5;4(150):<\/a> (abstract only)<\/li>\n<\/ul>\n
- Molecular basis of antimony treatment in Leishmaniasis J. Med. Chem.<\/em>, 2009, 52, 2603-12<\/a><\/li>\n<\/ul>\n
- Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem.<\/em> 284, 28977-85 (2009)<\/a><\/li>\n<\/ul>\n